01 - Combine ground beef with salt, pepper, garlic powder, and onion powder in a mixing bowl. Mix gently to avoid overworking the meat.
02 - Divide the seasoned beef into 8 equal portions and shape into small patties. Make each patty slightly wider than the slider buns to account for shrinkage during cooking.
03 - Heat a grill or skillet over medium-high heat until hot.
04 - Place patties on the hot cooking surface and cook for 2-3 minutes until well-browned. Flip each patty, top with a slice of cheddar cheese, and cook another 2-3 minutes until cheese melts and patties reach desired doneness.
05 - Lightly toast the slider buns on the grill or in a toaster until golden brown.
06 - Spread condiments on the bottom buns. Layer lettuce, cheese-topped beef patties, tomato slices, pickles, and red onion. Cover with the top buns and serve immediately.